Teignmouth failed find the rhythm and cohesion that was present in the previous cup win against Bovey Tracey and paid the price as Stoke Gabriel left Coombe Valley with all three points.
Adam Fay had two chances early in the game and had either found the back of the net the result could have been different.
Stoke's Wills tested home keeper Liam Jones with a drive from the edge of the box which the keeper held comfortably.
Far too often Teigns gave away possession in the middle of the park handing the initiative to their opponents, but it was not until midway through the first half that Stoke scored what would prove to be the winning goal.
Ty Hawkin burst through Teigns' defence and finished from the edge of the area.
Teigns almost had the perfect response when Ian Wilkinson opened up Stoke's defence only to hit his shot straight at Coombe.
Collings had a goal disallowed for the visitors for offside and only some clever defending from Jamie Surman prevented Hawkin from scoring.
Captain Alex Blackburn swept up well as Teigns' defenders came under increasing pressure.
With half-time imminent, Andy Breslan put Ashley Webber clear on the left, who swung a teasing cross into the path of Fay but Coombe was quick and snatched the ball off his toe.
Right on the stroke of half-time Jones again came to his side's rescue, saving another shot from Hawkin.
Teigns hadn't played well and were fortunate to only be one goal down, but they improved at the start of the second period,
Coombe had to be at his best to save Surman's header from a corner, then a rash tackle on Adam Hill by the last defender resulted in a direct free-kick, the referee deeming a yellow card sufficient for the offence.
Wilkinson took the free-kick but Coombe was well placed to gather the ball. Stoke responded and Jones produced an instinctive save from a snap-shot, with Hawkin heading the rebound against the bar.
Driven on from midfield by Craig Stonelake, Teigns pinned their visitors back, but as they pushed forward were susceptible to the counter attack, which Stoke sprang, and again Jones pulled off another good stop to deny Guy.
With 20 minutes left debutant Ross Casey came on for Surman and Lee Haywood replaced Webber.
Teigns switched their formation, moving Mark Dyson in from the wing to partner Fay up front.
Dyson won a free-kick on the edge of Stoke's penalty area, but Fay struck the ball into the defensive wall.
Jaime Dodge came off the bench for Andy Breslan and Blackburn joined the attack.
The switch almost paid off as Blackburn found space in the penalty area only to see his strike hit the side netting.
Stoke held out, protecting their one goal lead till the final whistle, to take the spoils.
This was a very disjointed performance from Teigns, and disappointing for joint managers Andy Paddon and Geoff Breslan, who were not too pleased with their team's application.
Teignmouth travel to face a resurgent Ottery St Mary tomorrow. Kick-off at Washbrook Meadow is 3pm.